Welcome to Takiyama Group。

~2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024 本、総説はこちら

2024

Shuntaro AMARI, Sae UNO, Tsubasa KASAI, Haruto YOSHIDA, Hiroshi TAKIYAMA, Toshikazu SUENAGA
Effect of operating condition on the properties of ectoine particles for improving the purification process.
Chemical Engineering Research and Design, 210, 664-669 (2024).
(DOI: 10.1016/j.cherd.2024.09.016) Free link before November 15, 2024

Sayaka ABE, Shuntaro AMARI, Hiroshi TAKIYAMA
Effects of aeration on the external shape of crystalline particles in reactive crystallization with pH modulation.
Journal of Chemical Engineering of Japan, 57(1), 2404068 (2024).
(DOI: 10.1080/00219592.2024.2404068)

Sayaka ABE, Shuntaro AMARI, Hiroshi TAKIYAMA
Effects of aeration timing on the desupersaturation and size distribution of product crystalline particles during cooling crystallization.
Powder Technology, 446(1), 120185 (2024).
(DOI: 10.1016/j.powtec.2024.120185) Free link before October 07, 2024

Bolor-Uyanga TUMURBAATAR, Shuntaro AMARI, Hiroshi TAKIYAMA
The effect of template reset operation on the number of crystals precipitated at the air–solution template interface.
Crystals, 14, 7, 591 (2024).
(DOI: 10.3390/cryst14070591)

Shuntaro AMARI, Ryuji TAKAHASHI, Mako HOSOKAWA, Hiroshi TAKIYAMA
Improving the quality of crystalline particles and productivity during anti-solvent crystallization through continuous flow with high shear stress under low supersaturation condition.
Advanced Powder Technology, 35, 6, 104493 (2024).
(DOI: 10.1016/j.apt.2024.104493) Free link before July 13, 2024

Bolor-Uyanga TUMURBAATAR, Shuntaro AMARI, Hiroshi TAKIYAMA
Dissolution performance enhancement of poorly water-soluble API by crystallization from phase-separated melt.
Chemical Engineering Research and Design, 203, 538-546 (2024).
(DOI: 10.1016/j.cherd.2024.02.009) Free link before April 4, 2024

Mako HOSOKAWA, Shuntaro AMARI, Hiroshi TAKIYAMA
Investigating the characteristics of MnCO3 crystalline particles under high shear field.
Powder Technology, 433, 119277 (2024).
(DOI: 10.1016/j.powtec.2023.119277) Free link before February 7, 2024

2023

Shuntaro AMARI, Sari OHASHI and Hiroshi TAKIYAMA
Effect of properties of microcrystals and impurities on the growth rate enhancement of crystalline particles in suspension.
Desalination, 2023, 567, 116987
(DOI: 10.1016/j.desal.2023.116987)

Sayaka ABE, Shuntaro AMARI and Hiroshi TAKIYAMA
Crystal size distribution and morphology control of sea urchin-like crystal by using irreversibility of external shape change.
Journal of Crystal Growth, 2023, 614, 127216
(DOI: 10.1016/j.jcrysgro.2023.127216)

Ryota MIYAMOTO, Shuntaro AMARI and Hiroshi TAKIYAMA
Effects of properties of crystalline particles on mother liquor holdup in crystal cake and residue behaviors of impurities.
Journal of Chemical Engineering of Japan, 2023, 56(1), 2201309
(DOI: 10.1080/00219592.2023.2201309)

Ryota MIYAMOTO, Shuntaro AMARI and Hiroshi TAKIYAMA
Comparison of the effects of crystalline particle size modified by crystallization on the mother liquor removal profiles of washing and reslurry.
Journal of Chemical Engineering of Japan, 2023, 56(1), 2206851
(DOI: 10.1080/00219592.2023.2206851)

2022

Shuntaro AMARI, Ai OKUDE, Shoji KUDO and Hiroshi TAKIYAMA
Operation strategy for avoiding oiling-out during the anti-solvent crystallization based on ternary phase diagram.
ChemistrySelect, 2022, 7, 45
(DOI: 10.1002/slct.202203181)

Ryo HARADA, Shozo ASAHI, Shuntaro AMARI and Hiroshi TAKIYAMA
Continuous anti-solvent crystallization of glycine β-form crystalline particles by taylor-vortex crystallizer.
Journal of Chemical Engineering of Japan, 2022, 55, 12, 365–369
(DOI: 10.1252/jcej.21we104)

Shuntaro AMARI, Ayano NAKAMURA, and Hiroshi TAKIYAMA
Effect of operating conditions on the characteristics of crystalline particles in a cascade-type crystallizer.
Industrial & Engineering Chemistry Research, 2022, 61, 28, 10117–10123
(DOI: 10.1021/acs.iecr.2c01358)
(Highlighted as a Supplementary Cover)

Shuntaro AMARI, Chinami SUGAWARA, Shoji KUDO and Hiroshi TAKIYAMA
Investigation of operation strategy based on solution pH for improving the crystal quality formed during reactive crystallization of L-aspartic acid.
ACS Omega, 2022, 7, 3, 2989–2995
(DOI: 10.1021/acsomega.1c06015)

Mitsuki OHYAMA, Shuntaro AMARI and Hiroshi TAKIYAMA
Operation design of co-crystallization by using homogeneity evaluation including "single component excess" index.
Journal of Chemical Engineering of Japan, 2022, 55, 1, 8-14
(DOI: 10.1252/jcej.21we090)

Kentaro ATSUKAWA, Shuntaro AMARI and Hiroshi TAKIYAMA
Effect of aeration operation on crystallization induction time of melt with the difficulty of nucleation.
Journal of Industrial and Engineering Chemistry, 2022, 106, 25, 69-73
(DOI: 10.1016/j.jiec.2021.10.023)

2021

Shuntaro AMARI, Chinami SUGAWARA, Ryo HARADA, Shoji KUDO and Hiroshi TAKIYAMA
Investigating the effect of operation points on crystal quality in reactive crystallization using continuous flow with high shear stress.
Chemical Engineering Research and Design, 2021, 176, 116-122
(DOI: 10.1016/j.cherd.2021.09.030)

Mitsuki OHYAMA, Shuntaro AMARI and Hiroshi TAKIYAMA
Operation design of reactive crystallization using homogeneity evaluation for the quality improvement of agglomerated crystalline particles.
Crystals, 2021, 11, 844
(DOI: 10.3390/cryst11080844)

Kentaro ATSUKAWA, Shuntaro AMARI and Hiroshi TAKIYAMA
Solid dispersion melt crystallization (SDMC) concept using binary eutectic system for improvement of dissolution rate.
Journal of Industrial and Engineering Chemistry, 2021, 54, 1, 12-17
(DOI: 10.1016/j.jiec.2021.05.032)

Soichiro URAI and Hiroshi TAKIYAMA
Improvement Rebaudioside D solubility by preparing a solid phase with erythritol using melt crystallization technology.
Journal of Chemical Engineering of Japan, 2021, 54, 1, 12-17
(DOI: 10.1252/jcej.20we192)

Soichiro URAI and Hiroshi TAKIYAMA
Investigation of improved rebaudioside D solubility and the characteristics of an erythritol/rebaudioside D/fructose ternary complex.
Food Science and Technology Research, 2021, 27, 2, 193-201
(DOI: 10.3136/fstr.27.193)

2020

Ryota MIYAMOTO, Shuntaro AMARI and Hiroshi TAKIYAMA
Evaluating the reslurry rate for particle design of spherical crystalline agglomerates via crystallization.
Journal of Chemical Engineering of Japan, 2020, 54, 2, 72-76
(DOI: 10.1252/jcej.19we200)

Mana KOYAMA, Shoji KUDO, Shuntaro AMARI and Hiroshi TAKIYAMA
Development of novel cascade type crystallizer for continuous production of crystalline particles.
Journal of Industrial and Engineering Chemistry, 2020, 89, 25, 111-114
(DOI: 10.1016/j.jiec.2020.06.021)

Kota TANAKA and Hiroshi TAKIYAMA
Impurities assisted with control of polymorphs during seeded crystallization.
Journal of Chemical Engineering of Japan, 2020, 53, 4, 160-166
(DOI: 10.1252/jcej.19we202)

Kota TANAKA and Hiroshi TAKIYAMA
Effect of solution composition on impurity profile of the crystallized product in oiling-out crystallization.
Chemical and Pharmaceutical Bulletin, 2020, 68, 4, 326-331
(DOI: 10.1248/cpb.c19-01015)

Soichiro URAI, Shoji KUDO and Hiroshi TAKIYAMA
Development of rebaudioside D polymorphs with improved solubility.
Food Science and Technology Research, 2020, 26, 1, 17-23
(DOI: 10.3136/fstr.26.17)

Kentaro ATSUKAWA, Shoji KUDO, Shuntaro AMARI and Hiroshi TAKIYAMA
Increase of solidification rate to improve quality of productivity for xylitol/sorbitol crystalline candy products.
Journal of Food Engineering, 2020, 268, 109738
(DOI: 10.1016/j.jfoodeng.2019.109738)

2019

Kota TANAKA and Hiroshi TAKIYAMA
Effect of oiling-out during crystallization on purification of an intermediate compound.
Organic Process Research & Development, 2019, 23, 9, 2001-2008
(DOI: 10.1021/acs.oprd.9b00256)

Eriko SATO, Yuichiro SEKI and Hiroshi TAKIYAMA
Control of reaction crystallization of organic compounds using the supersaturation profile.
Journal of Chemical Engineering of Japan, 2019, 52, 7, 599-604
(DOI: 10.1252/jcej.19we017)

Yuko YAMAGUCHI, Woo-Sik KIM and Hiroshi TAKIYAMA
Crystal quality control by using the millimeter-size tube type taylor vortex continuous crystallizer.
Journal of Chemical Engineering of Japan, 2019, 52, 3, 308-310
(DOI: 10.1252/jcej.18we024)

Eriko SATO, Shoji KUDO and Hiroshi TAKIYAMA
Study on control of pH-modulation crystallization utilizing concept of dissociation equilibrium.
Chemical and Pharmaceutical Bulletin, 2019, 67, 5, 461-466
(DOI: 10.1248/cpb.c18-01004)

Mitsuki OHYAMA, Shoji KUDO, Shuntaro AMARI and Hiroshi TAKIYAMA
Production of crystalline particles with high homogeneity in reaction crystallization by using pH-solubility-profile.
Journal of Industrial and Engineering Chemistry, 2019, 75, 38-43
(DOI: 10.1016/j.jiec.2019.03.003)

2018

Momoko NISHIMARU, Shoji KUDO and Hiroshi TAKIYAMA
Effect of two kinds of supersaturation on crystal qualities during cocrystallization.
Journal of Chemical Engineering of Japan, 2018, 52, 62, 579-585
(DOI: 10.1252/jcej.18we281)

Shoji KUDO and Hiroshi TAKIYAMA
Solubility determination for carbamazepine and saccharin in methanol/water mixed solvent: basic data for design of cocrystal production by antisolvent crystallization.
Journal of Chemical & Engineering Data, 2018, 63, 451-458
(DOI: 10.1021/acs.jced.7b00920)

Eriko SATO, Yutaka KAMEYAMA, Shoji KUDO and Hiroshi TAKIYAMA
Kinetic study on crystallinity change and degradation process of cefixime trihydrate during drying.
Journal of Chemical Engineering of Japan, 2018, 51, 5, 389-394
(DOI: 10.1252/jcej.17we270)

Shuichi WADA and Hiroshi TAKIYAMA
Proposal of evaluation method for amount of mother liquor in spherical agglomerates
Journal of Chemical Engineering of Japan, 2018, 51, 3, 269-275
(DOI: 10.1252/jcej.17we043)

Haruka SUZUKI and Hiroshi TAKIYAMA
Investigation of the change in morphology of glycine crystalline particles at the template interface with L-leucine
Journal of Chemical Engineering of Japan, 2018, 51, 3, 276-281
(DOI: 10.1252/jcej.17we206)

2017

Momoko NISHIMARU, Miku NAKASA, Shoji KUDO and Hiroshi TAKIYAMA
Operation condition for continuous anti-solvent crystallization of CBZ-SAC cocrystal considering deposition risk of undesired crystals
Journal of Crystal Growth, 2018, 470C, 89-93
(DOI: 10.1016/j.jcrysgro.2017.04.017)

Shuichi WADA and Hiroshi TAKIYAMA
Development of simultaneous control of polymorphism and morphology in indomethacin crystallization
Journal of Crystal Growth, 2016, 435, 37-41
(DOI: 10.1016/j.jcrysgro.2015.11.038)

Daiki NAGAMATSU, Norihito SATO and Hiroshi TAKIYAMA
Estimation of temperature dependency on crystallization using the critical supersaturation ratio (Sc)
Journal of Chemical Engineering of Japan, 2017, 50, 8, 66-668
(DOI: 10.1252/jcej.16we274)

2016

Haruka SUZUKI and Hiroshi TAKIYAMA
Observation and evaluation of crystal growth phenomena of glycine at the template interface with L-leucine
Advanced Powder Technology, 2016, 27, 2161-2167
(DOI: 10.1016/j.apt.2016.07.029)

Momoko NISHIMARU, Shoji KUDO and Hiroshi TAKIYAMA
Cocrystal production method reducing deposition risk of undesired single component crystals in anti-solvent cocrystallization
Journal of Industrial and Engineering Chemistry, 2016, 36, 40-43
(DOI: 10.1016/j.jiec.2016.01.027)

Kazuhiro, TAKEGUCHI, Kazuyoshi OBITSU, Shun HIRASAWA, Ryoki ORII, Shigeru IEDA, Minoru OKADA and Hiroshi TAKIYAMA
Effect of temperature and solvent of solvent-mediated polymorph transformation on ASP3026 polymorphs and scale-up
Organic Process Research & Development, 2016, 20, 970-976
(DOI: 10.1021/acs.oprd.6b00068)

2015

Shuichi WADA, Jun IIJIMA and Hiroshi TAKIYAMA
Crystallization operation method for recovering Mg resources from the sea water desalination process
Journal of Chemical Engineering of Japan, 2015, 48, 1, 94-98
(DOI: 10.1252/jcej.14we157)

Ai OKUDE and Hiroshi TAKIYAMA
Selective recrystallization of metastable polymorph of melt acetaminophen by using tempering operation
Journal of Industrial and Engineering Chemistry, 2015, 31, 263-268
(DOI: 10.1016/j.jiec.2015.06.035)

Kazuhiro TAKEGUCHI, Kazuyoshi OBITSU, Shun HIRASAWA, Ryoki ORII, Shigeru IEDA, Minoru OKADA and Hiroshi TAKIYAMA
Strategy for controlling polymorphism of di(arylamino) aryl compound ASP3026 and monitoring solution structures via raman spectroscopy
Organic Process Research & Development2015, 19, 1966-1972
(DOI: 10.1021/acs.oprd.5b00208)

Kazuhiro TAKEGUCHI, Yutaka HIRAKURA, Kouji YAMAZAKI, Itsuro SHIMADA, Shigeru IEDA, Minoru OKADA and Hiroshi TAKIYAMA
Characterization and thermodynamic stability of polymorphs of di(arylamino) Aryl compound ASP3026
Chemical and Pharmaceutical Bulletin, 2015, 63, 418-422
(DOI: 10.1248/cpb.c14-00774)

Shoji KUDO, Yutaka SUZAKI Tomomichi HINO, Shinpei KATO and Hiroshi TAKIYAMA
Growth and dissolution kinetics for methacrylic acid crystal in melt
Journal of Chemical Engineering of Japan, 2015, 48, 11, 922-926
(DOI: 10.1252/jcej.14we388)

Haruka SUZUKI and Hiroshi TAKIYAMA
Templated crystal nucleation phenomena at the air/solution interface focusing on the repulsive force
Journal of Chemical Engineering of Japan, 2015, 48, 6, 488-490
(DOI: 10.1252/jcej.14we386)

2014

Daiki NAGAMATSU, Yasuo IDA and Hiroshi TAKIYAMA
Evaluation of the difficulty of crystallization of organic compounds using the critical supersaturation ratio (Sc)
Journal of Crystal Growth, 2014, 406, 48-52
(DOI: 10.1016/j.jcrysgro.2014.08.012)

Shoji KUDO and Hiroshi TAKIYAMA
Production method of carbamazepine/saccharin cocrystal particles by using two solution mixing based on the ternary phase diagram
Journal of Crystal Growth, 2014, 392, 87-91
(DOI: 10.1016/j.jcrysgro.2014.02.003)

2013

Hirokuni YAMAMOTO and Hiroshi TAKIYAMA
Production of organic micro-crystals by using templated crystallization as nucleation trigger
Journal of Crystal Growth, 2013, 373, 69-72
(DOI: 10.1016/j.jcrysgro.2012.11.007)

Takuma MINAMISONO and Hiroshi TAKIYAMA
Control of polymorphism in the anti-solvent crystallization with a particular temperature profile
Journal of Crystal Growth, 2013, 362, 135-139
(DOI: 10.1016/j.jcrysgro.2011.11.091)

Shoji KUDO, Tomomichi HINO and Hiroshi TAKIYAMA
The effect of morphology of crystals in suspension on scale formation dynamics in cooling crystallization for organic compound
Journal of Chemical Engineering of Japan, 2013, 46, 11, 790-793
(DOI: 10.1252/jcej.13we140)

Tomomichi HINO, Shinpei KATO and Hiroshi TAKIYAMA
The purity of methacrylic acid crystals under the presence of maleic acid and methanol in melt crystallization
Journal of Chemical Engineering of Japan, 2013, 46, 11, 785-789
(DOI: 10.1252/jcej.13we132)

Tomomichi HINO, Shinpei KATO and Hiroshi TAKIYAMA
The influence of a small amount of maleic acid on crystal deposition phenomena of methacrylic acid in melt crystallization
Journal of Crystal Growth, 2013, 373, 142-145
(DOI: 10.1016/j.jcrysgro.2012.10.016)

2012

Hiroshi TAKIYAMA and Kenji ITO
Production of organic fine-crystalline particles by using the liquid-liquid interface in an emulsion
Chem. Eng. Technol., 2012, 35, 6, 991-994
(DOI: 10.1002/ceat.201200016)

Hiroshi TAKIYAMA
Supersaturation operation for quality control of crystalline particles in solution crystallization
Advanced Powder Technology, 2012, 23, 273-278
(DOI: 10.1016/j.apt.2012.04.009)

Mitsuru SHOJI and Hiroshi TAKIYAMA
The application of two-dimensional population balance model to study the effect of temperature profile on the crystal size distribution and aspect ratio
Crystal Growth & Design, 2012, 12, 5241-5246
(DOI: 10.1021/cg300680f)

Tomomichi HINO, Shinpei KATO and Hiroshi TAKIYAMA
Crystal growth phenomena of methacrylic acid under the presence of maleic acid in melt crystallization
Journal of Chemical Engineering of Japan, 2012, 45, 10, 868-872
(DOI: 10.1252/jcej.13we132)

Shoji KUDO, Tomomichi HINO and Hiroshi TAKIYAMA
Scale formation dynamics on cooling surface during start-up operation in melt crystallization
Journal of Chemical Engineering of Japan, 2012, 45, 7, 551-553
(DOI: 10.1252/jcej.11we254)

Shoji KUDO and Hiroshi TAKIYAMA
Production of fine organic crystalline particles by using milli segmented flow crystallizer
Journal of Chemical Engineering of Japan, 2012, 45, 4, 305-309
(DOI: 10.1252/jcej.11we168)

Takuma MINAMISONO Yoshiaki SATO, Hiroshi ISHIHARA, Takao OMAE, Takashi HASEBE and Hiroshi TAKIYAMA
Solid-state characterization of E3210 polymorphs
Journal of Chemical Engineering of Japan, 2012, 45, 3, 233-238
(DOI: 10.1252/jcej.11we191)

2011

Mitsuru SHOJI and Hiroshi TAKIYAMA
The influence of crystal orientation on crystal size measurement
Journal of Chemical Engineering of Japan, 2011, 44, 12, 999-1002
(DOI: 10.1252/jcej.11we190)

Takuma MINAMISONO, Takao OMAE, Takashi KATO and Hiroshi TAKIYAMA
Evaluation of the relative stability of toropane derivative nitrate polymorphs
Journal of Chemical Engineering of Japan, 2011, 44, 4, 197-207
(DOI: 10.1252/jcej.10we280)

Mitsuru SHOJI and Hiroshi TAKIYAMA
A kinetic study of the influence of modulated undersaturation operation on crystal size distribution in cooling-type batch crystallization
Journal of Chemical Engineering of Japan, 2011, 44, 3, 191-196
(DOI: 10.1252/jcej.10we251)

Takahiro NISHITA and Hiroshi TAKIYAMA
Influence of admixture impurities on the crystal quality of inorganic phosphorus compound
Journal of Chemical Engineering of Japan, 2011, 44, 2, 118-122
(DOI: 10.1252/jcej.10we206)

Tomomichi HINO, Shinpei KATO, Yugo Mizokoshi and Hiroshi TAKIYAMA
Solid-liquid equilibrium data for the binary system methacrylic acid + methanol in the high methacrylic acid concentration range
Fluid Phase Equilib., 2011, 312, 14-19
(DOI: 10.1016/j.fluid.2011.09.002)

2010

Hiroshi TAKIYAMA, Takuma MINAMISONO, Yohei OSADA, Masakuni MATSUOKA
Operation design for controlling polymorphism in the anti-solvent crystallization by using ternary phase diagram
Chemical Engineering Research and Design, 2010, 88, 1242-1247
(DOI: 10.1016/j.cherd.2009.09.011)

Takahiro NISHITA and Hiroshi TAKIYAMA
Inhibitory phenomena of crystal growth of inorganic phosphorus compounds by admixture impurities
KAGAKU KOGAKU RONBUNSHU, 2010, 36, 2, 105-110
(DOI: 10.1252/kakoronbunshu.36.105)

2009

Hiroshi TAKIYAMA
A study on modeling and control of salt crystallization under high suspension density conditions

～2008

Hiroshi TAKIYAMA and Yohei YAMANE
Effects of dissolution water injection methods on CSD in salt crystallization
Bulletin of the Society of Sea Water Science, Japan, 2008, 62 292-293
(DOI: 10.11457/swsj1965.62.292)

Hirohisa UCHIDA, Atsushi MANAKA, Masakuni MATSUOKA and Hiroshi TAKIAYAMA
Growth phenomena of single crystals of naphthalene in supercritical carbon dioxide
Crystal Growth & Design, 2004, 4, 5, 937-942
(DOI: 10.1021/cg034212u)

Yukiko MARUI, Masakuni MATSUOKA, Hirohisa UCHIDA and Hiroshi TAKIAYAMA
Analysis and simulation of phase transformation kinetics of zeolite a from amorphous phases
Journal of Chemical Engineering of Japan, 2003, 36, 5, 616-622
(DOI: 10.1252/jcej.36.616)

Yukiko MARUI, Hirohisa UCHIDA, Hiroshi TAKIAYAMA and Masakuni MATSUOKA
Nucleation rates of zeolite a crystals from clear aluminosilicate solutions
Journal of Chemical Engineering of Japan, 2003, 36, 5, 597-602
(DOI: 10.1252/jcej.36.597)

Hirohisa UCHIDA, Hiroshi TAKIAYAMA and Masakuni MATSUOKA
Molecular dynamics simulation of the solution structure near the solid-liquid interface between the NaCl(100) and NaCl-KCl-H2O solutions
Crystal Growth & Design, 2003, 3, 2, 209-213)
(DOI: 10.1021/cg025513r)

Maiko YAMANOBE, Hiroshi TAKIAYAMA and Masakuni MATSUOKA
FT-IR study on the effect of solvents on polymorphic crystallization of organic compounds
Journal of Chemical Engineering of Japan, 2002, 35, 6, 569-573)
(DOI: 10.1252/jcej.35.569)

本?総説Books/Review article

Hiroshi TAKIYAMA
Advances in Organic Crystal Chemistry Comprehensive Reviews 2020

滝山 博志
晶析の強化書【増補新版】～有機合成者でもわかる晶析操作と結晶品質の最適化～

Hiroshi TAKIYAMA
Advances in Organic Crystal Chemistry Comprehensive Reviews 2015

滝山 博志
晶析の強化書【増補版】～有機合成者でもわかる晶析操作と結晶品質の最適化～

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